Psoralea corylifolia L. Seed Extract Attenuates Methylglyoxal-Induced Insulin Resistance by Inhibition of Advanced Glycation End Product Formation

Figure 2

PCS extract treatment increases expression of insulin-stimulated p-Akt and pIRS1/2 in MGO-administered mice. Liver tissues were obtained from mice 10 min after insulin injection, and western blot was performed for p-Akt and pIRS1/2. (a) A representative blot is shown. The intensity of band was quantified using the Image Lab software. (b) Quantification of p-Akt/actin from (a). (c) Quantification of p-IRS/actin from (a). Data are shown as (, independent experiments); . CON: control; MGO: methylglyoxal; MGO+PCS 200: methylglyoxal+PCS extract 200 mg/kg; MGO+PCS 500: methylglyoxal+PCS extract 500 mg/kg; MGO+AG: methylglyoxal+aminoguanidine.

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