Apolipoprotein E Deficiency Aggravates Neuronal Injury by Enhancing Neuroinflammation via the JNK/c-Jun Pathway in the Early Phase of Experimental Subarachnoid Hemorrhage in Mice

Figure 2

APOE deficiency aggravated neurological deficit within 72 h after SAH. (a) APOE^-/- SAH mice exhibited a lower tendency of survival percentage than WT mice. However, the difference was nonsignificant. (b) APOE^-/- mice exhibited a more severe motor deficit than WT mice at both time points (, ; for each group). (c) SAH induced weight loss of all mice (, compared to sham). Weight loss of APOE^-/- mice exceeded that of WT mice at 48 h and 72 h after SAH (^#, ^##; for each group). (d) No difference was observed between APOE^-/- and WT mice in the SAH grade.

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