Research Article
Prognostic Value of Oxidative Stress Markers in Patients with Pulmonary Arterial or Chronic Thromboembolic Pulmonary Hypertension
Table 5
Comparison of clinical and laboratory parameters in patients with clinical worsening vs. stable patients.
| | Characteristics | Clinical worsening () | Stable () | value |
| | Gender | | | 0.17 | | Female | 7 (50) | 23 (74) | | Male | 7 (50) | 8 (26) | | Age (years) | 64 (42-74) | 62 (49-71) | 0.64 | | WHO FC (, %) | | | 0.017 | | I or II | 6 (43) | 25 (81) | | III or IV | 8 (57) | 6 (29) | | peakVO2 (mL/kg/min) | 14.2 (12.0-15.3) | 17.3 (13.75-21.05) | 0.039 | | 6MWT (m) | 380.5 (180-510) | 480 (360-525) | 0.17 | | RAA (cm2) | 25.5 (19.0-37.0) | 20.3 (16.0-26.9) | 0.08 | | Fluid in pericardium (, %) | 5 (36) | 2 (6) | 0.023 | | NT-pro-BNP (pg/mL) | 612.0 (98.0-1905.0) | 206.0 (122.0-476.0) | 0.13 | | RDW (%) | 15.6 (13.8-16.2) | 14.2 (13.3-15.0) | 0.16 | | Troponin I (ng/mL) | 0.042 (0.0010-0.115) | 0.000 (0.0000-0.0005) | 0.0017 | | mPAP (mmHg) | 39.0 (34.0-48.0) | 38.5 (30.0-50.0) | 0.84 | | PVR (Wood units) | 449.0 (290.0-592.0) | 360.8 (247.0-536.0) | 0.65 | | CI (L/min/m2) | 3.4 (3.1-4.1) | 3.5 (3.0-4.1) | 0.97 | | mRAP (mmHg) | 7.0 (4.0-8.0) | 6.0 (4.0-7.0) | 0.53 | | SatO2mix (%) | 73.6 (66.0-75.8) | 74.5 (68.1-79.4) | 0.26 | | TAC (mM) | 0.41 (0.24-0.48) | 0.64 (0.54-0.72) | 0.027 | | MDA (μM) | 3.86 (3.06-4.56) | 2.25 (0.98-3.54) | 0.0041 | | CAT (U/L) | 1.23 (1.16-1.33) | 1.57 (1.2-2.5) | 0.028 | | SOD (%) | 78.88 (75.40-83.61) | 79.88 (77.02-82.77) | 0.67 |
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WHO FC: World Health Organization Functional Class; peakVO 2: peak oxygen consumption; 6MWT: 6-minute walking test; RAA: right atrium area; NT-pro-BNP: N-terminal B-type natriuretic peptide; RDW: red blood cell distribution width; mPAP: mean pulmonary artery pressure; PVR: pulmonary vascular resistance; CI: cardiac index; mRAP: mean right atrium pressure; SatO 2mix: mixed venous oxygen saturation; PAH: pulmonary arterial hypertension; CTEPH: chronic thromboembolic pulmonary hypertension; TAC: total antioxidant capacity; MDA: malondialdehyde; CAT: catalase activity; SOD: superoxide activity; value refers to the Mann-Whitney test or the Fisher exact test. |
