Crosstalk between Mitochondrial Ca²⁺ Uptake and Autophagy in Skeletal Muscle

Figure 4

Mitochondrial Ca²⁺ uptake measurements in skATG7^−/− mice. (a) Resting mitochondrial [Ca²⁺] was decreased in skATG7^−/− FDB myofibers compared to ATG7^fl/fl controls. Data are presented as (>10 fibers per condition). (b) Ratiometric measurements of mitochondrial Ca²⁺ uptake upon caffeine treatment highlighted a reduction in peak mitochondrial [Ca²⁺] of skATG7^−/− FDB myofibers compared to ATG7^fl/fl controls. , test (two-tailed, unpaired) of >10 fibers per condition. Data are presented as . (c) Representative traces of mitochondrial Ca²⁺ uptake measurements.

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