Hepatoprotective Activity of Vitamin E and Metallothionein in Cadmium-Induced Liver Injury in Ctenopharyngodon idellus

Figure 2

Histopathological changes in the livers induced by cadmium and detoxification-treated livers collected on the 4th, 12th, and 16th days after challenge with cadmium and treatment with VE and MT. (a–c) The liver of the control group. (d–f) Histopathological changes in the liver in the PBS group with time. (d) The arrow shows congestion in hepatic sinusoids. (e) The number of inflammatory cells increased in the blood vessels and hepatic sinusoids on the 12th and 16th days postchallenge. The arrow shows inflammatory cells. (f) Necrotic and apoptotic cells present in pancreatic cells. The arrows show cell degeneration and necrosis. (g–i) Histopathological changes in the liver in the VE group with time. (g) Hyperemia did not significantly improve during the Cd challenge in the VE group on the 4th day. The arrows show red blood cells. (h, i) Hepatopancreas recovered on the 12th and 16th days in the VE group. The arrows show pancreatic cells restored. (j–l) Histopathological changes in the liver in the MT group with time. (j) Hyperemia did not significantly improve during the Cd challenge in the MT group on the 4th day. The arrows show pancreas congestion. (k, l) Inflammatory cells decreased on the 12th and 16th days and hepatopancreas damage recovered. The arrows show red cells in the pancreas decreased.