Protective Effects of a Polyphenol-Rich Extract from Syzygium cumini (L.) Skeels Leaf on Oxidative Stress-Induced Diabetic Rats

Figure 6

Cell proliferation and insulin release induced by PESc. Cell proliferation was determined by BrdU incorporation to DNA, whereas insulin levels were determined by commercial ELISA kit—both described in the Materials and Methods section. (a) Cell proliferation after 48 hours of incubation with or w/o PESc. Results expressed as relative to w/o PESc condition. (A) versus w/o PESc and (B) versus all. per group. (b) Glucose-stimulated insulin secretion (GSIS) in INS-1E insulinoma cells incubated with 100 or 1000 μg/mL PESc for 4 hours at 37°C. (A) versus w/o PESc; (B) versus PESc 100 μg/mL; (C) versus PESc 1000 μg/mL. per group. All data were analyzed by one-way ANOVA followed by Tukey posttest and presented as mean ± SEM.

(a)

(b)