Research Article
Cyclodextrin Enhances Corneal Tolerability and Reduces Ocular Toxicity Caused by Diclofenac
Table 2
Contact angle, surface tension measurements, spreading, flux, and apparent permeability coefficient of diclofenac sodium from solution and cyclodextrin complexes. Results presented as mean values ± SD,
. denotes statistically significant differences (
).
| | Formulation | Contact angle (θ) | Surface tension (mN/m) | Spreading coefficient | Steady-state flux (μg/h) | Papp × 10−6 (cm/s) |
| | Diclo | 34 ± 0.65 | 52.0 ± 2.5 | −8.9 ± 2.00 | 53 ± 1.5 | 12.0 ± 0.5 | | Diclo-α-CD | 52 ± 0.55 | 65.5 ± 1.0 | −25.2 ± 1.0 | 21 ± 0.7 | 5.0 ± 0.5 | | Diclo-β-CD | 50 ± 0.45 | 61.5 ± 2.0 | −22.0 ± 1.5 | 19 ± 2.8 | 4.3 ± 1.0 | | Diclo-γ-CD | 52 ± 0.80 | 60.35 ± 2.8 | −23.2 ± 1.5 | 41.5 ± 3.5 | 9.4 ± 2.0 | | Diclo-HP-β-CD | 53 ± 0.55 | 61.33 ± 2.0 | −24.4 ± 2.0 | 41 ± 4.5 | 9.3 ± 2.0 |
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