Lycopene: Hepatoprotective and Antioxidant Effects toward Bisphenol A-Induced Toxicity in Female Wistar Rats

Table 4

Effect of LYC on hepatic tissue antioxidant enzyme activities, lipid peroxidation level, caspase-3 immunoreactivity, and comet tail DNA % in BPA-intoxicated female Wistar rats.

Parameter	Experimental groups
	Control	LYC	BPA	BPA + LYC
GPx (nmol/mg)	99.06 ± 3.79^b	108.85 ± 2.95^a	61.14 ± 0.90^d	88.62 ± 1.71^c
SOD (U/mg)	7.60 ± 1.50^a	7.62 ± 0.01^a	5.74 ± 0.05^c	6.74 ± 0.04^b
MDA (nmol/mg)	0.54 ± 0.00^c	0.52 ± 0.01^c	0.93 ± 0.02^a	0.72 ± 0.02^b
CYPR450 (ng/g)	3.86 ± 0.04^a	3.98 ± 0.01^a	2.44 ± 0.04^c	3.44 ± 0.08^b
Caspase-3 IRA (%)	35.62 ± 4.82^c	42.74 ± 5.71^c	77.04 ± 2.97^a	61.86 ± 3.09^b
Comet tail DNA (%)	6.68 ± 1.04^c	6.94 ± 1.29 ^c	25.05 ± 2.93^a	14.50 ± 2.61^b

Values are expressed as means ± SE () in every group. BPA: bisphenol A; LYC: lycopene, GPx: glutathione peroxidase; SOD: superoxide dismutase, MDA: malondialdehyde, CYPR450: cytochrome P450 reductase; IRA: immunoreactive area. Within the same row, means with different superscript letters differ significantly at .