Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38^MAPK, and JNK Kinase Pathways

Table 1

Effects of specific kinase inhibitors on HuR cytoplasmic accumulation, its threonine phosphorylation, and p62 increase, compared to the AICAR + MG132 cotreatment.

	Kinase targeted by inhibition	HuR cytoplasmic accumulation	HuR phosphorylation	p62 protein levels
AICAR + MG132		↑	↑	↑
	Erk1/2	↓	↓	↓
	AMPK	—	—	—
	p38^MAPK	—	↓	↓
	JNK	—	↓	↓
	cPKC	—	↓	—

↑: increase; ↓: decrease; —: no variation. For further details, see the text.