Growth Inhibition of a Novel Iron Chelator, DpdtC, against Hepatoma Carcinoma Cell Lines Partly Attributed to Ferritinophagy-Mediated Lysosomal ROS Generation

Figure 9

The effect of lysosomal ROS on autophagy and TRMPL1. A: Western blot analysis; B: quantification analysis. The data were obtained from three independent Western blots based on comparison of the investigated protein with Gapdh (1) control; (2) 1 μM DpdtC; (3) 1 μM DpdtC + 1.5 mM 3-MA; (4) 1 μM DpdtC + 1.5 mM NAC; (5) 1.5 mM 3-MA; (6) 1.5 mM NAC. (; ; one-way ANOVA).

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