Review Article

The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease

Table 3

H2S-releasing compounds used in basic scientific researches.

CompoundsConstituentsEffects on research fields

SACS-allylcysteineProtection on cardiovascular and neural systems
SPRCS-propargyl-cysteineAnticancer, anti-inflammation, and antihypoxic/ischemia and impairs cognition and Aβ-induced neuronal damage
GYY4137Morpholin-4-ium-4-methoxyphenyl (morpholino) phosphinodithioateAntagonizes endotoxic shock though anti-inflammatory effects
ACS-6A H2S-donating sildenafilInhibits superoxide formation and gp91phox expression in porcine PAECs
ACS-14A H2S-releasing aspirinRegulates redox imbalance, such as GSH formation, HO-1 promoter activity, and isoprostane suppression
ACS-15A H2S-releasing derivative of diclofenacArthritis
ACS-67A H2S-releasing derivative of latanoprost acidGlaucoma; retinal ischemia
ATB-284A H2S-releasing derivative of trimebutineIrritable bowel syndrome
ATB-337A H2S-releasing derivative of diclofenacGastrointestinal damage induced by NSAIDs
ATB-346A H2S-releasing derivative of naproxenAcute and chronic joint pain
ATB-429A H2S-releasing derivative of mesalamineInflammatory bowel disease and antinociceptive and anti-inflammatory effects
IK 1001Calcium-cross-linked alginate polymerSuspended animation, multiple hypoxic/ischemic conditions, cardiac remodeling, and congestive heart failure