Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway

<div>SIRT1 siRNA and Nrf2 siRNA transfection blunted HKL-induced antiapoptotic effects against SIR injury in HG-treated H9c2 cells. (a) Cellular morphology (100x). (b) Cellular viability. (c) Representative images of TUNEL staining (200x, bar = 200 <i>μ</i>m). The apoptotic cells were detected by TUNEL (green), and the nuclei were detected by DAPI (blue). (d) Cellular apoptotic index. (e) Representative blots. (f) Bcl-2/Bax ratio. (g) Cleaved caspase 3 expression. (h) Cytosolic cytochrome <i>c</i> expression. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway 

Figure 6 | Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway 