Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway

Figure 1

Type 1 diabetic rats subjected to MI/R surgery showed further weakened cardiac function, increased myocardial oxidative stress and apoptosis, and reduced myocardial SIRT1 signaling. (a) Representative M-mode images by echocardiography. Echocardiographic assessment was performed after 72 h of reperfusion. (b) Left ventricular ejection fraction (LVEF). (c) Left ventricular fractional shortening (LVFS). (d) Representative blots. (e) SIRT1 expression. (f) Relative SIRT1 activity. (g) Bcl-2/Bax ratio. (h) Cleaved caspase 3 expression. (i) gp91^phox expression. (j) Representative images of DHE staining (300x, bar = 100 μm). (k) DHE intensity. Data are presented as the mean ± SEM ( in each group). versus the sham group, versus the Con group.

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