The Ability of Different Ketohexoses to Alter Apo-A-I Structure and Function In Vitro and to Induce Hepatosteatosis, Oxidative Stress, and Impaired Plasma Lipid Profile in Hyperlipidemic Zebrafish

Table 2

Serum profile of zebrafish after consumption of high cholesterol diet and ketohexose for 3 weeks.

	ND^1; ()	HCD^2; ()	HCHF^3; ()	HCHT^4; ()
Weight (mg)/height (mm)	9.2 ± 1.6	9.9 ± 2.0	8.9 ± 1.5	9.3 ± 1.9
Total cholesterol (mg/dL)	108 ± 5	385 ± 15	330 ± 2	407 ± 34
Tricylglyceride (mg/dL)	232 ± 10	271 ± 51	311 ± 31	194 ± 13
Glucose (mg/dL)	54 ± 16	73 ± 18	105 ± 25	83 ± 26
GOT (Karmen/mL)	178 ± 4	221 ± 31	271 ± 27	191 ± 17
CETP activity (% CE-transfer/4 h)	37 ± 1	48 ± 6	49 ± 1	42 ± 0

¹ND: normal diet, Tetrabit®: Tetrabit (47.5% crude protein, 6.5% crude fat, 2.0% crude fiber, 10.5% crude ash, containing vitamin A [29,770 IU/kg], vitamin D3 [1860 IU/kg], vitamin E [200 mg/kg], and vitamin C [137 mg/kg]). ²HC: high cholesterol (4% cholesterol in ND, wt/wt). ³HCHF: high cholesterol and high fructose (50% fructose in HCD, wt/wt). ⁴HCHT: high cholesterol and high tagatose (50% tagatose in HCD, wt/wt). Data were analyzed by ANOVA Bonferroni t-test. Levels of significance were represented in the form of , when compared with initial (ND) group. TC: total cholesterol; TG: triglycerides; GOT: glutamate oxaloacetate transaminase; CETP: cholesteryl ester transfer protein.