Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress

Figure 9

Effect of aripiprazole on ROS production in the brain of PSD mice. Reactive oxygen species (ROS) production was assessed by dihydroethidium (DHE) fluorescence staining. Representative photomicrographs of the fluorescence of DHE oxidation in the nucleus accumbens (a), hippocampus (b), and hypothalamus (c) of control (Con), sham (PSD), and aripiprazole-treated mice (PSD + APZ). The fluorescence of DHE oxidation is shown as red fluorescence (arrows), and nuclear DNA was labeled with blue fluorescence by DAPI. Scale . (d) Quantification graphs of DHE fluorescence intensity. Data are expressed as (). and vs. control; , , and vs. PSD.

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