Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress

Figure 3

IDO1 expression in the brain of PSD mice. (a) Representative images of immunofluorescent staining for indoleamine 2,3-dioxygenase 1 (IDO1) in the striatum (Str), nucleus accumbens (NAc), hippocampus (Hippo), and hypothalamus (Hypo). Significantly higher levels of IDO1 immunoreactivity were observed in NAc, Hippo, and Hypo, but not in the Str of PSD mice. IDO1 was labeled with red fluorescence, and nuclear DNA was labeled with blue fluorescence by DAPI. The yellow dashed rectangle marks the position of an enlarged image of IDO1. Scale . (b) Schematic diagram shows the regions of the striatum (Str), nucleus accumbens (NAc), hippocampus (Hippo), and hypothalamus (Hypo) of the brain. (c) Quantification of IDO1 fluorescence intensity. Data are expressed as (). and vs. control.

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