Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress

Figure 2

Spatial restraint stress after MCAO showed depressive-like behaviors and cognitive impairment. Body weight (a), sucrose preference test (b), and forced swim test (c) were performed at 5, 7, and 9 weeks after completing MCAO and spatial restraint stress. In the Morris water maze test, representative swimming traces (d) and percent of time spent (e) in the target quadrant where the hidden platform was previously placed during the probe trial session at 10 weeks after MCAO. (f) Corticosterone levels in serum were determined by commercial ELISA. Data are expressed as (). , , and vs. control.

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