RTA-408 Protects Kidney from Ischemia-Reperfusion Injury in Mice via Activating Nrf2 and Downstream GSH Biosynthesis Gene

<div>RTA-408’s protective role in renal tubule cell apoptosis and proliferation. (a) Representative images (magnification 400x; scale bar 50 <i>μ</i>m) of TUNEL immunostaining in the injured kidney at 24 h reperfusion. (b) Quantification of TUNEL-positive cells by an average number of 5 HPF in different groups. 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(c) Representative Ki67 immunostaining result (magnification 400x; scale bar 50 <i>μ</i>m) in the injured kidney at different time points after reperfusion. (d) Quantification of Ki67-positive cells by an average number of 5 HPF in different groups. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: RTA-408 Protects Kidney from Ischemia-Reperfusion Injury in Mice via Activating Nrf2 and Downstream GSH Biosynthesis Gene 