Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model

<div>Effect of resveratrol treatment on Akt-1<sup>Ser473</sup> and GSK-3<i>β</i><sup>Ser9</sup>. Representative Western blot analysis of Akt-1<sup>Ser473</sup>, GSK-3<i>β</i><sup>Ser9</sup>, and p38-MAPK<sup>Thr180-Gly-Tyr182</sup> and phosphorylation and densitometric evaluation are shown. GAPDH was used as a loading control. Representative blots and bar diagrams of three independent experiments are presented. C: control animals; RES: animals treated with resveratrol for 8 weeks; ISO: animals 8 weeks after ISO administration; ISO + RES: animals treated with resveratrol, 8 weeks after ISO administration. 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36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path></g><g transform="matrix(.013,0,0,-0.013,17.737,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z" id="g117-91"></path></g><g transform="matrix(.013,0,0,-0.013,29,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,35.24,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path></g><g transform="matrix(.013,0,0,-0.013,38.204,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 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id="g113-54"></path></g></svg> (C versus RES).</div>

Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model 