Spermidine Oxidation-Mediated Degeneration of Retinal Pigment Epithelium in Rats

Figure 3

Spermidine-induced impairment of electroretinogram (ERG) a- and b-wave amplitudes in rats. Scotopic ERG a- and b-waves were measured on days 2, 6, 13, and 27 days after the intravitreal administration of spermidine. Traces typical of (a) control, (b) spermidine (10 nmol/eye), (c) spermidine (20 nmol/eye), and (d) spermidine (30 nmol/eye) treatments, 13 days after the injection are shown. Time course data of (e) ERG a-waves and (f) ERG b-waves are shown. Each value represents the mean ± standard error of the mean of seven to eight eyes. and versus control.

(a) Control day 13

(b) Spermidine (10 nmol/eye) day 13

(c) Spermidine (20 nmol/eye) day 13

(d) Spermidine (30 nmol/eye) day 13

(e) ERG a-wave

(f) ERG b-wave