Neuroprotective and Cognitive-Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome

Figure 3

Effect of microencapsulated mulberry fruit extract on density of survival neurons in the various subregions of the hippocampus. (a) Light microscope of coronal sections in CA1, CA2, CA3, and dentate gyrus of the hippocampus were stained with cresyl violet at 40x magnification. (b) Density of survival neurons in CA1, CA2, CA3, and dentate gyrus of the hippocampus. Data are presented as mean ± SEM (/group). value < 0.01 and value < 0.001, compared to control rats which received normal diet and vehicle; value < 0.05, compared to normal rats which received HCHF diet and vehicle; and value < 0.05, value < 0.01, value < 0.001, compared to OVX rats which received HCHF and vehicle. ND: normal diet; HCHF: high-carbohydrate high-fat diet; OVX-HCHF: ovariectomized plus high-carbohydrate high-fat diet; Iso: the isoflavone at dose of 15 mg·kg⁻¹ BW; MME10, 50, and 250: the microencapsulated mulberry fruit extract at dose of 10, 50, and 250 mg·kg⁻¹ BW, respectively.

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