Neuroprotective and Cognitive-Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome

Figure 2

Effect of microencapsulated mulberry fruit extract (MME) on memory impairment via Morris Water Maze test ((a) escape latency time, (b) retention time). Data are presented as mean ± SEM (/group). value < 0.05 and value < 0.01, compared to control rats which received normal diet and vehicle; value < 0.001, compared to normal rats which received HCHF diet and vehicle; and value < 0.05, value < 0.01, value < 0.001, compared to OVX rats which received HCHF and vehicle. ND: normal diet; HCHF: high-carbohydrate high-fat diet; OVX-HCHF: ovariectomized plus high-carbohydrate high-fat diet; Iso: the isoflavone at dose of 15 mg·kg⁻¹ BW; MME10, 50, and 250: the microencapsulated mulberry fruit extract at dose of 10, 50, and 250 mg·kg⁻¹ BW, respectively.

(a)

(b)