Review Article
Protein Glutathionylation in the Pathogenesis of Neurodegenerative Diseases
Table 1
Summary of the glutathionylated proteins involved in neurodegenerative diseases.
| Disease | Target protein of glutathionylation | Effect of glutathionylation | Reference |
| AD | Glyceraldehyde-3-phosphate dehydrogenase | Inhibition of α-enolase activity | [58] | p53 | Possibly prevention of its tetramer formation | [60] | α-Enolase | Inactivation | [58] |
| PD | Mitochondrial NADP+-dependent isocitrate dehydrogenase | Inhibition of its activity | [85] | ATP synthase β subunit | Possible regulation of complex V assembly | [86] |
| HD | TRPC5 | Activation of Ca2+ channel | [105] |
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