Effects of Novel Nitric Oxide-Releasing Molecules against Oxidative Stress on Retinal Pigmented Epithelial Cells

Figure 8

Molecular docking into Keap1 domains. (a) Semiflexible docking at the Keap1-DC domain of curcumin (grey stick) and K67 (PDB:4ZY3, green stick). (b) Covalent docking—Michael addition at the Cys151 of the BTB domain of Keap1. (c) 2D pose representation of VP10/39 covalent bound (black hatched line) to Cys151 of the Keap1-BTB domain. (d) 2D pose representation of VP10/12 covalent bound (black hatched line) to Cys151 of the Keap1-BTB domain.

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