Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation

Table 5

Effect of probucol on myocardial KEAP1 and NRF2 expression 12 h after ROSC (; ).

Group	Protein expression level
	KEAP1	NFE2L2
Sham operated	2.18 ± 0.67	5.67 ± 0.09
CA model	11.53 ± 2.48	4.28 ± 0.11
CA + low dose	7.36 ± 1.83^‡	4.46 ± 0.10^†
CA + medium dose	7.03 ± 1.38^‡	5.13 ± 0.09^‡
CA + high dose	5.43 ± 1.44^‡¶††	5.35 ± 0.16^‡§

versus the sham-operated group; ^† and ^‡ versus the CA model group; ^§ and ^¶ versus the low-dose group; ^†† versus the medium-dose group. KEAP1: Kelch-like ECH-associated protein 1; NFE2L2: nuclear factor, erythroid-derived 2-like 2; ROSC: return of spontaneous circulation.