Demethoxycurcumin Preserves Renovascular Function by Downregulating COX-2 Expression in Hypertension

Figure 2

In vivo treatment with DMC corrects the downregulation of P-eNOS expression and the upregulation of COX-2 in the renal arteries isolated from vehicle-treated SHR. Western blot assay reveals decreased P-eNOS (Ser1177) expression and elevated COX-2 expression, which were corrected by DMC treatment for 3 weeks ((a)-(b)). Data are means ± SEM of 5-6 experiments. versus WKY; SHR + vehicle.

(a)

(b)