Demethoxycurcumin Preserves Renovascular Function by Downregulating COX-2 Expression in Hypertension

Figure 1

In vivo treatment with DMC reduces blood pressure in SHR and improves the deteriorated renovascular endothelial function. WKY rats exhibited blood pressure of  mmHg. Higher blood pressure in SHR was reduced after 3-week treatment with DMC (downregulation of 13.48% after treatment, ; (a)). Blunted ACh-induced relaxation and pronounced ACh-induced contractions were observed in the renal arteries of vehicle-treated SHR compared to the normotensive WKY controls ((b)-(c)). Chronic oral treatment with DMC (10 mg/kg/day for 3 weeks) enhanced the relaxations and inhibited contractions. Relaxation induced by SNP remained similar among the three groups. Data are means ± SEM of 7-8 experiments. versus WKY; SHR + vehicle.

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(b)

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