Overview of Alzheimer’s Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds

Figure 7

(a) Proposed model for AD pathology based on abnormal metal interaction. Cu and Fe levels increase during aging in the CNS and result in increase in metal and Aβ interaction. Cu binding to Aβ results in ROS production and autooxidation of Aβ peptide. Oxidized Aβ contributes to synaptic pathology and plaque formation. Metals may also promote phosphorylation of tau and hence enhance formation of NFT which further contribute to AD pathology. (b) Model showing the amyloid-copper interaction. Notice the coordination sites at His 6 from one peptide together with His13 and His14 from the second peptide.

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