Research Article

Conservation of the Nrf2-Mediated Gene Regulation of Proteasome Subunits and Glucose Metabolism in Zebrafish

Table 2

The pathways activated in both nrf2a-overexpressing embryos and DEM/tBHQ-treated larvae.

valuePathway nameGenes

Glutathione conjugationgclc, gsto2, gstp1, gclm, gsta.1
Phase II conjugationgclc, gsto2, gstp1, ugdh, gclm, gsta.1
Detoxification of reactive oxygen speciestxn, gstp1, prdx1, gsr
Biological oxidationsgclc, gstp1, gsto2, aoc2, ugdh, gclm, gsta.1
Vitamin C (ascorbate) metabolismgsto2
Sulfur amino acid metabolismgclc, sqrdl, gclm
TP53 regulates metabolic genestxn, prdx1, gsr
Glutathione synthesis and recyclinggclc, gclm
Cellular responses to stresstxn, gstp1, prdx1, gsr
Metabolismgclc, pck1, gstp1, sqrdl, txn, gsta.1, gsr, pcxb, gsto2, aoc2, pgd, ugdh, gclm

Bold genes encode enzymes related to the glucose metabolism process.