Review Article
The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression
Table 2
HIF-dependent genes in hypoxia adaptation in determining malignancy hallmarks.
| HIF-dependent genes | Adaptation phenotype | ROS effect | References |
| VEGFs and VEGFRs | Neoangiogenesis, repair | Indirect | [63–65] | TERT (telomerase) | telomere length and proliferative potential | Direct and indirect | [66–69] | Cyclin D1, cyclin D2 | Increased proliferation | Indirect | [70] | TERT; c-Myc, SOX2, OCT4, KLF4, Notch | Stem cell renewal, differentiated cell reprogramming | Indirect | [71, 72] | ABC transporter | Drug resistance | Indirect | [75–77] | ALDA, PGK, GLUT-1 | Changes in energy metabolism | Indirect | [61, 78] | PDGF, chemokine receptors | Motility and polarized migration | Indirect | [104, 105] | MMP9, MMPs | Integrity of basement membrane; invasiveness | Direct and indirect | [97–100] | Alarmin (DAMPs) receptors | NFκB activation; IRR gene express | Indirect | [80–82] |
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