Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More

Table 3

Protective effect of quercetin against oxidative stress and cytotoxicity in mouse striatal astrocytes.

	ROS (% of basal)	Cytotoxicity (IC50, μM)
Control
H2O2	630	39
DMNQ	695	37
+ Quercetin
H2O2	130	157
DMNQ	115	131

For ROS measurements, control or quercetin-pretreated cells (24 h, 20 μM) were exposed to either oxidant for 30 min. For cytotoxicity (assessed by the MTT assay) control or quercetin pretreated cells were exposed for 24 h to 4-5 concentrations of oxidants. Significantly different from control, . Adapted from [34].