Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More

Table 2

Neuroprotection by quercetin against neurotoxicants in vivo.

Animal	Neurotoxicant	Quercetin	Effect of quercetin	Ref.
M, F Wistar; rats	Lead (0.2% in water through pre- and postnatal development)	30 mg/kg/d for 7 d starting at PND 60	Decreased lipid perox. in hippocampus; partial reversal of LTP	[38]
M Wistar; rats	PCBs (Aroclor 1254); 2 mg/kg/d for 30 d i.p.	50 mg/kg/d for 30 d, orally	Decreased ox. stress in cerebellum; reduced dopaminergic toxicity	[39]
M Wistar; rats	MeHg 30 mg/kg/d for 45 d, orally	0.5, 5, and 50 mg/kg/d for 45 d, orally	Decreased reduction of GSH, GPx (5, 50 mg/kg)	[40]
M C57BL/6; mice	MPTP 30 mg/kg/d for 4 d (10–14 of Q)	50, 100, and 200 mg/kg/d for 14 d	Diminished reduction of DA levels, SOD, and GPx	[41]
M Wistar; rats	Endosulfan 2 mg/kg/d, for 6 d, orally	10 mg/kg/d, for 6 d, orally	Diminished lipid perox. and mitochondria swelling	[42]
M Wistar; rats	Tungsten 100 ppm in water for 3 mo.	0.3 mM/d for 3 mo., orally	Reduced oxidative stress	[43]

F: female; GPx: glutathione peroxidase; GSH: glutathione; M: male; MeHg: methylmercury; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PCBs: polychlorinated biphenyls; PND: postnatal day; SOD: superoxide dismutase.