Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative Stress

Table 1

Potential cardiotoxicity induced by numerous chemotherapeutic agents.

Class	Examples of chemotherapeutic agents	Possible cardiotoxicity
Anthracyclines and anthraquinones	DOX, mitoxantrone	Congestive heart failure, left ventricular dysfunction, acute myocarditis, and arrhythmia
Antimetabolite agents	Capecitabine, 5-fluorouracil, and cytarabine	Ischemia, pericarditis, congestive heart failure, and cardiogenic shock
Antimicrotubule agents	Paclitaxel, vinca alkaloids	Sinus bradycardia, ventricular tachycardia, atrioventricular block, hypotension, congestive heart failure, and ischemia
Alkylating agents	Cyclophosphamide, ifosfamide	Neurohumoral activation, mild mitral regurgitation
Monoclonal antibody against HER2	Trastuzumab	Arrhythmias, congestive heart failure, angioedema, and left ventricular dysfunction
Antiangiogenic and tyrosine kinase inhibitors	Imatinib, sorafenib, and sunitinib	Hypertension, arrhythmias
Antivascular endothelial growth factor	Bevacizumab	Hypertension, thromboembolism