Nitric Oxide Regulates Neurogenesis in the Hippocampus following Seizures

Figure 7

NO decreases the number of newborn neurons born 3 days after seizures in iNOS^+/+ mice. (a) Orthogonal projections of representative images of BrdU-positive cells (BrdU+) shown green and NeuN-positive (NeuN+) cells, shown red. Scale bar: 20 μm. Assessment of the percentage of BrdU-NeuN colocalizing cells in the dentate gyrus of iNOS^+/+ or iNOS^−/− mice, 3 days (b) or 7 days (c) following SE. At least 3 surviving animals were used for each experimental group. Data are expressed as means ± SEM. Two-factor ANOVA (Bonferroni’s posttest): to 7; , significantly different from iNOS^+/+ saline.

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