Deconstructing Mitochondrial Dysfunction in Alzheimer Disease

Figure 1

AD-related alterations of mitochondrial respiratory chain and tricarboxylic acid cycle. Scheme of alterations in protein levels found in Alzheimer disease brains as well as the targets of amyloid-β (Aβ) and phosphorylated Tau (pTau). Oxidative phosphorylation complexes are labeled as CI to CIV. PDH: pyruvate dehydrogenase, α-KG: α-ketoglutarate, α-KGDH: α-ketoglutarate dehydrogenase, OAA: oxaloacetate.