Research Article
Acute and Subchronic Toxicological Study of the Cocktail Extract from Curcuma xanthorrhiza Roxb, Phyllanthus niruri L. and Morinda citrifolia L.
Table 4
Effect of CECPM on hematological profile of rats in sub-chronic oral toxicity study.
| | Sex | Parameters | Groups | | Control | CECPM (600 mg/kg·bw) | CECPM (800 mg/kg·bw) | CECPM (1000 mg/kg·bw) | Satellite | | Control | CECPM (1000 mg/kg·bw) |
| | Females♀ | RBC (106/μL) | 8.58 ± 0.55 | 8.56 ± 1.00 | 8.10 ± 1.86 | 8.76 ± 0.30 | 8.56 ± 0.63 | 8.68 ± 0.29 | | HGB (g/dL) | 15.77 ± 0.81 | 15.37 ± 1.55 | 14.53 ± 3.24 | 15.87 ± 0.54 | 15.6 2 ± 1.23 | 15.71 ± 0.48 | | HCT (%) | 44.76 ± 2.15 | 43.69 ± 4.32 | 44.44 ± 3.32 | 44.74 ± 1.15 | 44.34 ± 3.34 | 44.61 ± 0.94 | | MCV (fL) | 52.23 ± 1.90 | 51.16 ± 1.87 | 51.29 ± 2.48 | 51.07 ± 1.03 | 51.83 ± 0.97 | 51.43 ± 1.35 | | MCH (pg) | 18.40 ± 0.47 | 18.01 ± 0.52 | 17.97 ± 0.67 | 18.14 ± 0.26 | 18.24 ± 0.31 | 18.12 ± 0.42 | | MCHC (g/dL) | 35.25 ± 0.60 | 35.18 ± 0.42 | 35.06 ± 1.06 | 35.47 ± 0.53 | 35.23 ± 0.37 | 35.21 ± 0.39 | | PLT (103/μL) | 935.22 ± 160.81 | 1078.11 ± 217.48 | 839.43 ± 286.16 | 1022.67 ± 158.71 | 909.90 ± 317.85 | 934.70 ± 312.13 | | WBC (103/μL) | 9.93 ± 2.16 | 8.64 ± 2.82 | 7.10 ± 2.95 | 10.01 ± 3.09 | 10.74 ± 2.77 | 10.09 ± 1.57 | | NEU (103/μL) | 2.50 ± 1.07 | 2.76 ± 0.76 | 1.85 ± 1.25 | 2.41 ± 0.93 | 3.40 ± 0.86 | 3.30 ± 0.51 | | LYM (103/μL) | 6.18 ± 1.32 | 4.83 ± 1.97 | 4.43 ± 1.56 | 6.15 ± 1.64 | 5.90 ± 2.04 | 5.50 ± 1.17 | | MONO (103/μL) | 0.76 ± 0.36 | 0.70 ± 0.28 | 0.52 ± 0.37 | 0.69 ± 0.30 | 1.10 ± 0.33 | 0.96 ± 0.19 | | EOS (103/μL) | 0.35 ± 0.19 | 0.36 ± 0.22 | 0.19 ± 0.18 | 0.52 ± 0.39 | 0.35 ± 0.16 | 0.33 ± 0.17 |
| | Males♂ | RBC (106/μL) | 9.98 ± 0.35 | 9.57 ± 0.42 | 9.53 ± 0.94 | 9.81 ± 0.59 | 9.90 ± 0.93 | 10.11 ± 0.46 | | HGB (g/dL) | 16.55 ± 0.46 | 16.44 ± 0.85 | 16.53 ± 1.09 | 16.59 ± 0.99 | 16.36 ± 1.65 | 16.83 ± 0.58 | | HCT (%) | 47.48 ± 1.64 | 47.01 ± 2.23 | 47.26 ± 3.10 | 47.18 ± 2.76 | 46.43 ± 4.27 | 47.73 ± 1.84 | | MCV (fL) | 47.63 ± 1.99 | 50.16 ± 4.12 | 49.76 ± 2.68 | 48.12 ± 1.93 | 46.81 ± 0.94 | 47.29 ± 2.01 | | MCH (pg) | 16.60 ± 0.56 | 17.20 ± 0.62 | 17.40 ± 0.82 | 16.93 ± 0.82 | 16.52 ± 0.37 | 16.65 ± 0.48 | | MCHC (g/dL) | 34.87 ± 0.46 | 34.96 ± 0.42 | 35.04 ± 0.34 | 35.16 ± 0.50 | 35.30 ± 0.52 | 35.26 ± 0.60 | | PLT (103/μL) | 983.80 ± 179.22 | 874.10 ± 198.58 | 811.10 ± 306.07 | 760.33 ± 313.10 | 1040.25 ± 167.68 | 923.70 ± 325.93 | | WBC (103/μL) | 13.03 ± 2.45 | 11.39 ± 2.60 | 11.25 ± 1.76 | 11.74 ± 3.21 | 12.75 ± 3.14 | 14.09 ± 1.93 | | NEU (103/μL) | 2.70 ± 0.47 | 3.08 ± 0.49 | 3.29 ± 0.82 | 2.96 ± 0.81 | 3.20 ± 0.60 | 3.55 ± 0.81 | | LYM (103/μL) | 8.56 ± 2.12 | 7.65 ± 2.20 | 6.76 ± 1.21 | 7.10 ± 1.91 | 7.12 ± 1.67 | 7.97 ± 1.63 | | MONO (103/μL) | 1.06 ± 0.28 | 0.97 ± 0.25 | 0.97 ± 0.27 | 0.97 ± 0.25 | 1.21 ± 0.37 | 1.31 ± 0.28 | | EOS (103/μL) | 0.37 ± 0.23 | 0.31 ± 0.20 | 0.41 ± 0.30 | 0.30 ± 0.19 | 0.25 ± 0.18 | 0.35 ± 0.25 |
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Data are expressed as means ± SD of ten animals in each group.
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