Research Article
Acute and Subchronic Toxicological Study of the Cocktail Extract from Curcuma xanthorrhiza Roxb, Phyllanthus niruri L. and Morinda citrifolia L.
Table 3
Body weight, organ weights, and relative organ weights of male rats treated orally with CECPM for 90 days.
| Parameters | Groups | Control | CECPM (600 mg/kg bw) | CECPM (800 mg/kg bw) | CECPM (1000 mg/kg bw) | Satellite | Control | CECPM (1000 mg/kg bw) |
| Body weight | Initial weight (g) | 238.48 ± 23.93 | 249.43 ± 23.34 | 230.05 ± 37.29 | 240.30 ± 35.12 | 250.47 ± 19.35 | 235.70 ± 42.46 | Final weight (g) | 350.33 ± 42.92 | 339.27 ± 27.88 | 333.50 ± 29.34 | 341.06 ± 43.27 | 358.43 ± 34.22 | 365.22 ± 72.27 | Body weight again (g) | 111.85 ± 35.96 | 89.84 ± 30.99 | 103.45 ± 36.97 | 100.76 ± 36.11 | 107.96 ± 26.34 | 127.52 ± 84.31 | Food intake (g) | 26.56 ± 3.03 | 27.23 ± 3.41 | 21.10 ± 3.69 | 27.81 ± 3.39 | 28.04 ± 3.21 | 27.00 ± 2.90 | Organ weight | Kidney (g) | 2.33 ± 0.23 | 2.14 ± 0.21 | 2.14 ± 0.20 | 2.28 ± 0.29 | 2.20 ± 0.24 | 2.28 ± 0.43 | Liver (g) | 9.48 ± 1.45 | 8.96 ± 0.97 | 8.92 ± 1.03 | 9.53 ± 2.31 | 8.55 ± 2.94 | 10.73 ± 2.67 | Spleen (g) | 0,76 ± 0.14 | 0.67 ± 0.20 | 0.56 ± 0.07 | 0.66 ± 0.11 | 0.59 ± 0.13 | 0.60 ± 0.13 | Heart (g) | 1.03 ± 0.16 | 1.03 ± 0.09 | 1.02 ± 0.10 | 1.04 ± 0.14 | 1.01 ± 0.12 | 1.03 ± 0.17 | Lung (g) | 2.48 ± 0.66 | 2.51 ± 0.78 | 2.85 ± 1.00 | 3.60 ± 2.75 | 3.68 ± 1.04 | 2.91 ± 0.72 | Relative organ weight | Kidney (%) | 0.67 ± 0.03 | 0.63 ± 0.04 | 0.64 ± 0.03 | 0.67 ± 0.05 | 0.62 ± 0.05 | 0.63 ± 0.04 | Liver (%) | 2.70 ± 0.13 | 2.64 ± 0.09 | 2.67 ± 0.18 | 2.79 ± 0.51 | 2.39 ± 0.83 | 2.94 ± 0.24 | Spleen (%) | 0.22 ± 0.04 | 0.20 ± 0.04 | 0.17 ± 0.02a | 0.20 ± 0.03 | 0.16 ± 0.03 | 0.17 ± 0.02 | Heart (%) | 0.29 ± 0.03 | 0.30 ± 0.02 | 0.31 ± 0.02 | 0.31 ± 0.02 | 0.28 ± 0.02 | 0.28 ± 0.02 | Lung (%) | 0.70 ± 0.14 | 0.74 ± 0.22 | 0.85 ± 1.00 | 1.08 ± 0.87 | 1.04 ± 0.32 | 0.82 ± 0.21 |
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Data are expressed as the means ± SD of ten animals in each group. a compared to the control group. |