Acute and Subchronic Toxicological Study of the Cocktail Extract from Curcuma xanthorrhiza Roxb, Phyllanthus niruri L. and Morinda citrifolia L.

Table 1

The body weight and relative organ weights of mice treated orally with CECPM for 14 days.

Parameters	Groups
	Control	CECPM (313 mg/kg·bw)	CECPM (625 mg/kg·bw)	CECPM (1250 mg/kg·bw)	CECPM (2500 mg/kg·bw)	CECPM (5000 mg/kg·bw)
Body weight
Initial weight (g)	36.68 ± 2.47	33.08 ± 3.51	36.04 ± 3.05	35.82 ± 3.72	36.24 ± 1.40	34.52 ± 2.89
Final weight (g)	38.90 ± 2.28	36.36 ± 3.17	38.76 ± 6.05	38.82 ± 4.01	39.80 ± 1.07	37.88 ± 2.61
Body weight gain (g)	2.22 ± 0.40	3.28 ± 4.46	2.72 ± 3.89	3.00 ± 1.49	3.56 ± 0.59	3.32 ± 1.16
Organ weight
Kidney (g)	0.42 ± 0.03	0.43 ± 0.04	0.40 ± 0.04	0.44 ± 0.09	0.46 ± 0.02	0.43 ± 0.08
Liver (g)	2.06 ± 0.12	1.19 ± 0.19	1.92 ± 0.20	2.09 ± 0.23	2.04 ± 0.23	2.04 ± 0.23
Spleen (g)	0,16 ± 0.02	0.21 ± 0.03	0.20 ± 0.04	0.19 ± 0.05	0.23 ± 0.10	0.23 ± 0.10
Heart (g)	0.16 ± 0.02	0.16 ± 0.04	0.16 ± 0.03	0.16 ± 0.03	0.14 ± 0.01	0.14 ± 0.01
Lung (g)	0.23 ± 0.04	0.21 ± 0.05	0.22 ± 0.03	0.26 ± 0.07	0.26 ± 0.03	0.26 ± 0.03
Relative organ weight
Kidney (%)	1.07 ± 0.10	1.22 ± 0.13	1.03 ± 0.09	1.14 ± 0.16	1.14 ± 0.19	1.14 ± 0.19
Liver (%)	5.30 ± 0.29	5.38 ± 0.42	4.99 ± 0.35	5.38 ± 0.25	5.40 ± 0.53	5.40 ± 0.53
Spleen (%)	0.41 ± 0.07	0.60 ± 0.07	0.51 ± 0.10	0.48 ± 0.11	0.61 ± 0.29	0.61 ± 0.29
Heart (%)	0.40 ± 0.04	0.44 ± 0.60	0.42 ± 0.06	0.41 ± 0.06	0.38 ± 0.03	0.38 ± 0.03
Lung (%)	0.59 ± 0.11	0.60 ± 0.13	0.59 ± 0.12	0.65 ± 0.11	0.67 ± 0.05	0.67 ± 0.05

Data are expressed as means ± SD of five animals in each group.