Protective and Ameliorative Effects of Hydroethanolic Extract of Piper nigrum (L.) Stem against Antiretroviral Therapy-Induced Hepatotoxicity and Dyslipidemia in Wistar Rats
Table 1
Effect of the 17 mg/kg TLE regimen and PNS extract on the hematological profile.
Normal
Neg. control
Positive control
ART + PNS200
ART + PNS400
ART + PNS800
White blood cells (103/μL)
12.60 ± 2.78
11.50 ± 0.95
13.57 ± 1.14
11.77 ± 1.54
10.05 ± 1.45
8.53 ± 1.83
Lymphocytes (103/μL)
9.60 ± 2.48
8.60 ± 0.82
9.47 ± 0.90
8.66 ± 1.14
7.79 ± 1.09
6.43 ± 1.55
Monocytes (103/μL)
0.53 ± 0.34
0.17 ± 0.01
0.66 ± 0.27
0.21 ± 0.07
0.15 ± 0.03
0.11 ± 0.04
Neutrophils (103/μL)
2.36 ± 0.19
2.59 ± 0.32
3.30 ± 0.49
2.75 ± 0.37
2.03 ± 0.36
1.95 ± 0.34
Eosinophils (103/μL)
0.06 ± 0.01
0.11 ± 0.02
0.08 ± 0.019
0.12 ± 0.03
0.04 ± 0.02
0.02 ± 0.01
Platelets (103/μL)
504.80 ± 133.92
878.30 ± 70.84
737.33 ± 72.40
794.50 ± 89.33
649.83 ± 113.40
1108.75 ± 99.56a
Red blood cells (106/μL)
10.11 ± 1.01
8.39 ± 0.60
8.22 ± 0.51
7.39 ± 0.73
8.27 ± 1.30
8.54 ± 0.54
Hemoglobin (g/dL)
17.06 ± 1.74
14.80 ± 0.64
14.55 ± 0.59
14.00 ± 0.78
15.81 ± 1.16
14.06 ± 1.18
Hematocrit (%)
71.92 ± 7.50
61.31 ± 3.50
59.28 ± 2.71
55.06 ± 4.44
60.40 ± 8.73
59.70 ± 4.96
Mean cell volume (fL)
71.18 ± 0.97
73.60 ± 1.98
72.60 ± 1.88
75.61 ± 2.79
74.78 ± 2.39
71.33 ± 2.10
Mean cell hemoglobin (pg)
16.86 ± 0.24
17.98 ± 1.25
17.91 ± 0.96
20.15 ± 2.93
23.26 ± 5.95
16.80 ± 0.05
Mean cell hemoglobin concentration (g/dL)
23.76 ± 0.23
24.33 ± 1.05
24.61 ± 0.65
26.16 ± 2.59
30.2 ± 6.36
23.56 ± 0.65
Values are expressed as mean ± SEM, n = 6. Nor = administered distilled water; Neg = ART only; Pos = ART + silymarin; ART + PNS 200 mg; ART + PNS 400 mg; ART + PNS 800 mg. a significant difference from the normal control group.
