Protective and Ameliorative Effects of Hydroethanolic Extract of Piper nigrum (L.) Stem against Antiretroviral Therapy-Induced Hepatotoxicity and Dyslipidemia in Wistar Rats

Figure 6

Effect of the 17 mg/kg TLE and PNS extract on the antioxidant enzymes in the liver. Each bar represents mean ± SEM, n = 6. Nor = administered distilled water; Neg = ART only; Pos = ART + silymarin; ART + PNS 200 mg; ART + PNS 400 mg; ART + PNS 800 mg; a, b, c, d, e, f, and g represent significant differences with respect to the normal group in each assay, while 1, 2, and 3 represent a significant difference with respect to the negative control group. CAT was measured in mM of H₂O₂/ming of organ, GSH in mol/g of organ, and SOD in unit/mg of protein. CAT = catalase; SOD = superoxide dismutase; GSH = reduced glutathione.