Assessment of Acute and Chronic Toxicity in Wistar Rats (Rattus norvegicus) and New Zealand Rabbits (Oryctolagus cuniculus) of an Enriched Polyphenol Extract Obtained from Caesalpinia spinosa
Table 6
Effects of P2Et extract on biochemical parameters in rabbits following 180 days of administration.
Parameters and reference values
Group
value
Test (N = 7)
Control (N = 5)
Kidney function
Urea (13.0 to 52.0 mg/dL)
51.37 ± 12.83
48.50 ± 6.76
0.66
Creatinine (0.80 to 1.80 mg/dL)
1.28 ± 0.29
1.27 ± 0.15
0.91
Sodium (138.0 to 148.0 mmol/L)
146.20 ± 2.13
146.30 ± 1.81
0.93
Potassium (3.3 to 6.9 mmol/L)
4.84 ± 0.27
4.76 ± 0.17
0.55
Chloride (92.0 to 112.0 mmol/L)
99.04 ± 2.84
101.36 ± 2.50
0.17
Calcium (5.6 to 12.0 mg/dL)
12.17 ± 0.35
12.62 ± 0.74
0.19
Liver function
ALT (31 to 60 U/L)
81.43 ± 17.90
88.00 ± 26.23
0.62
Phosphatase (90 to 145 U/L)
36.14 ± 5.58
45.40 ± 27.49
0.50
AST (42.0 to 98.0 U/L)
28.86 ± 7.20
31.40 ± 11.93
0.65
GGT (4 to 12 U/L)
5.86 ± 1.46
5.40 ± 0.55
0.81
Bilirubin (0.30 to 0.80 mg/dL)
0.30 ± 0.08
0.23 ± 0.11
0.23
Cholesterol (35 to 60 mg/dL)
45.00 ± 0.00
47.20 ± 3.90
0.26
Triglycerides (124 to 156 mg/dL)
48.76 ± 5.59
55.48 ± 20.56
0.81
N: number of animals in the group, data expressed as mean ± standard deviation. ALT: alanine transaminase; AST: aspartate aminotransferase; GGT: gamma-glutamyl transferase.
