Research Article
Acute and Subchronic Toxicity Assessment of Conventional Soxhlet Cymbopogon citratus Leaves Extracts in Sprague–Dawley Rats
Table 5
Effect of six weeks of oral administration of CSE C. citratus ethanolic extract on renal function test at termination of the experiment.
| Parameter | Treatment group | Control | Conventional soxhlet ethanolic C. citratus extract | 200 mg/kg | 600 mg/kg | 1200 mg/kg |
| Urea (mmol/L) | 9.12 ± 0.59 | 8.11 ± 0.27 | 8.28 ± 0.06 | 6.79 ± 0.54 | Creatinine (μmol/L) | 34.53 ± 1.61 | 30.55 ± 9.75 | 52.48 ± 13.25 | 50.28 ± 11.39 | Sodium (mmol/L) | 142.35 ± 0.85 | 142.1 ± 1.23 | 143.15 ± 1.63 | 142.05 ± 0.37 | Chloride (mmol/L) | 98.58 ± 1.04 | 100.13 ± 0.55 | 99.55 ± 0.45 | 99.95 ± 0.52 | Potassium (mmol/L) | 4.73 ± 0.75 | 5.08 ± 0.41 | 5.25 ± 0.52 | 3.75 ± 0.09 |
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Values are mean ± SEM of n = 6, , compared to control. |