Acute and Subchronic Toxicity Assessment of Conventional Soxhlet Cymbopogon citratus Leaves Extracts in Sprague–Dawley Rats

Table 4

Effect of six weeks of oral administration of CSE C. citratus ethanolic extract on liver function test at termination of the experiment.

Parameter	Treatment group
	Control	Conventional soxhlet ethanolic C. citratus extract
		200 mg/kg	600 mg/kg	1200 mg/kg
ALT (U/L)	61.08 ± 7.47	79.53 ± 9.33	57.93 ± 4.62	58.45 ± 3.76
AST (U/L)	20.30 ± 5.31	9.95 ± 2.60	22.00 ± 7.90	15.60 ± 0.46
ALP (U/L)	212.83 ± 6.72	294.25 ± 41.82	226.43 ± 40.54	266.78 ± 17.20
GGT (U/L)	7.38 ± 2.42	9.38 ± 4.35	8.00 ± 1.49	4.90 ± 0.68
Total protein (g/L)	79.15 ± 3.09	76.75 ± 2.11	71.40 ± 2.25	73.20 ± 0.88
Albumin (g/L)	36.28 ± 2.09	34.85 ± 1.07	35.78 ± 1.66	34.60 ± 0.50
Total bilirubin (µmol/L)	3.02 ± 0.19	2.73 ± 0.45	3.38 ± 0.32	5.06 ± 1.40
Direct bilirubin (μmol/L)	1.28 ± 0.12	1.14 ± 0.20	1.23 ± 0.23	1.13 ± 0.03
Indirect bilirubin (μmol/L)	2.63 ± 0.78	1.65 ± 0.29	2.15 ± 0.30	2.68 ± 0.66

Values are mean ± SEM of n = 6, , compared to control. ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase.