Research Article
Acute and Subchronic Toxicity Assessment of Conventional Soxhlet Cymbopogon citratus Leaves Extracts in Sprague–Dawley Rats
Table 4
Effect of six weeks of oral administration of CSE C. citratus ethanolic extract on liver function test at termination of the experiment.
| Parameter | Treatment group | Control | Conventional soxhlet ethanolic C. citratus extract | 200 mg/kg | 600 mg/kg | 1200 mg/kg |
| ALT (U/L) | 61.08 ± 7.47 | 79.53 ± 9.33 | 57.93 ± 4.62 | 58.45 ± 3.76 | AST (U/L) | 20.30 ± 5.31 | 9.95 ± 2.60 | 22.00 ± 7.90 | 15.60 ± 0.46 | ALP (U/L) | 212.83 ± 6.72 | 294.25 ± 41.82 | 226.43 ± 40.54 | 266.78 ± 17.20 | GGT (U/L) | 7.38 ± 2.42 | 9.38 ± 4.35 | 8.00 ± 1.49 | 4.90 ± 0.68 | Total protein (g/L) | 79.15 ± 3.09 | 76.75 ± 2.11 | 71.40 ± 2.25 | 73.20 ± 0.88 | Albumin (g/L) | 36.28 ± 2.09 | 34.85 ± 1.07 | 35.78 ± 1.66 | 34.60 ± 0.50 | Total bilirubin (µmol/L) | 3.02 ± 0.19 | 2.73 ± 0.45 | 3.38 ± 0.32 | 5.06 ± 1.40 | Direct bilirubin (μmol/L) | 1.28 ± 0.12 | 1.14 ± 0.20 | 1.23 ± 0.23 | 1.13 ± 0.03 | Indirect bilirubin (μmol/L) | 2.63 ± 0.78 | 1.65 ± 0.29 | 2.15 ± 0.30 | 2.68 ± 0.66 |
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Values are mean ± SEM of n = 6, , compared to control. ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase. |