Acute and Subchronic Toxicity Assessment of Conventional Soxhlet Cymbopogon citratus Leaves Extracts in Sprague–Dawley Rats

Table 3

Effect of six weeks of oral administration of CSE C. citratus ethanolic extract on haematological parameters at termination.

Parameter	Treatment group
	Control	Conventional soxhlet ethanolic C. citratus extract
		200 mg/kg	600 mg/kg	1200 mg/kg
WBC (×10^9/L)	18.6 ± 5.21	13.18 ± 4.74	10.15 ± 0.74	10.83 ± 0.74
Lymph# (×10^9/L)	11.98 ± 2.43	6.63 ± 1.05	6.58 ± 0.64	6.85 ± 0.81
Mid# (×10^9/L)	1.50 ± 0.35	1.13 ± 0.33	0.88 ± 0.08	1.00 ± 0.14
Gran# (×10^9/L)	5.13 ± 2.55	5.43 ± 3.39	2.70 ± 0.34	2.98 ± 0.79
Lymph (%)	68.05 ± 4.58	58.73 ± 8.13	64.68 ± 3.65	63.63 ± 6.71
Mid (%)	8.38 ± 0.51	8.80 ± 0.56	8.78 ± 0.42	9.15 ± 1.16
Gran (%)	23.58 ± 4.89	32.48 ± 8.41	26.55 ± 3.48	27.23 ± 5.73
RBC (×10^12/L)	8.11 ± 0.27	8.43 ± 0.36	8.21 ± 0.15	8.61 ± 0.08
HB (g/dL)	16.70 ± 0.60	15.98 ± 0.39	15.60 ± 0.12	15.88 ± 0.30
HCT (%)	50.48 ± 1.15	48.90 ± 1.40	47.85 ± 0.44	48.05 ± 0.39
MCV (fL)	56.83 ± 1.76	58.18 ± 0.94	58.40 ± 1.55	55.85 ± 0.47
MCH (pg)	18.78 ± 0.71	19.03 ± 0.44	19.00 ± 0.52	18.45 ± 0.31
MCHC (g/dL)	33.03 ± 0.43	32.48 ± 0.37	32.58 ± 0.28	33.08 ± 0.59
RDW-CV (%)	17.63 ± 0.42	18.90 ± 0.29	18.85 ± 0.34	18.18 ± 0.34
RDW-SD (fL)	33.33 ± 1.41	36.55 ± 0.84	36.55 ± 1.02	33.80 ± 0.62
PLT (×10^9/L)	772.30 ± 60.25	915.25 ± 86.13	912.75 ± 81.81	848.25 ± 33.16
MPV (fL)	6.63 ± 0.23	6.65 ± 0.09	6.70 ± 0.011	6.53 ± 0.08
PDW	14.58 ± 0.09	14.50 ± 0.04	14.55 ± 0.06	14.40 ± 0.04
PCT (%)	0.51 ± 0.04	0.61 ± 0.06	0.61 ± 0.05	0.56 ± 0.02
P-LCR	0.08 ± 0.01	0.07 ± 0.01	0.07 ± 0.01	0.06 ± 0.00

Values are mean ± SEM of n = 6, , compared to control.