Acute and Subchronic Toxicity Assessment of Conventional Soxhlet Cymbopogon citratus Leaves Extracts in Sprague–Dawley Rats

Table 1

Acute toxicity study of the effect of conventional Soxhlet C. citratus leaves extract in Sprague–Dawley rats over 14 days.

Time	Mortality		Toxicity signs
	Dead/treated rat	Latency (h)
0 hr	0/6	—	None
12 hr	0/6	—	None
24 hr	0/6	—	None
48 hr	0/6	—	None
3 days	0/6	—	None
4 days	0/6	—	None
5 days	0/6	—	None
6 days	0/6	—	None
7 days	0/6	—	None
8 days	0/6	—	None
9 days	0/6	—	None
10 days	0/6	—	None
11 days	0/6	—	None
12 days	0/6	—	None
13 days	0/6	—	None
14 days	0/6	—	None

The ethanolic conventional Soxhlet C. Citratus leaves extract was orally administered to six rats at a single dose of 5000 mg/kg bw.t. Observation for signs of toxicity was recorded after (12, 24, and 48) hr and (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14) days after the treatment. The control group was administered with 1 m/100 g bw.t of normal saline. 0/6: no deaths recorded. None: no signs of toxicity were observed over the study period. Latency: time to death (hours) after the treatment. —: latent period.