Acute and Subchronic Toxicity Assessment of Conventional Soxhlet Cymbopogon citratus Leaves Extracts in Sprague–Dawley Rats

Figure 7

Representative micrographs of the liver tissue in Sprague–Dawley rats after six weeks of CSE C. citratus ethanolic extract administration (x100). The micrographs show central veins (CV) surrounded by radiating plates of hepatocytes. Also shows blood vessels, including portal triads (PT) consisting of a branch of the hepatic artery, portal vein, and bile duct. No inflammatory cells present and necrosis in all treatment groups. (a) Liver tissue of control rats treated with sterilized distilled water. (b) Liver tissue of rats treated with 200 mg/kg bw.t CSE C. citratus ethanolic extract. (c) Liver tissue of rats treated with 600 mg/kg bw.t CSE C. citratus ethanolic extract. (d) Liver tissue of rats treated with 1200 mg/kg bw.t CSE C. citratus ethanolic extract.

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