Assessment of Safety Profile of Activated Curcumin C3 Complex (AC3®), Enriched Extract of Bisdemethoxycurcumin from the Rhizomes of Curcuma longa
Table 8
Effect of 90 days exposure to AC3® on hematological parameters in Wistar rats.
Parameter
Sex
Vehicle control
Treated
Control recovery
High dose-500 mg/kg b.w recovery
Low dose-125 mg/kg b.w
Mid dose-250 mg/kg b.w
High dose-500 mg/kg b.w
WBC (109/L)
M
12.47 ± 2.53
11.92 ± 3.14
10.94 ± 2.87
10.55 ± 3.99
11.00 ± 2.74
9.82 ± 3.50
F
7.94 ± 2.63
8.38 ± 2.12
8.25 ± 3.27
8.39 ± 2.58
8.92 ± 1.84
9.44 ± 2.64
RBC (1012/L)
M
9.15 ± 0.51
9.35 ± 0.46
9.10 ± 0.49
9.09 ± 0.28
9.63 ± 0.48
9.65 ± 0.48
F
8.09 ± 0.56
8.31 ± 0.38
8.37 ± 0.37
8.52 ± 0.46
8.56 ± 0.40
8.62 ± 0.33
Hemoglobin (g/L)
M
150.90 ± 3.87
154.10 ± 5.80
149.00 ± 6.88
152.20 ± 3.91
160.90 ± 7.06
157.10 ± 2.02
F
138.80 ± 10.90
140.80 ± 5.59
143.10 ± 4.33
145.10 ± 7.36
146.60 ± 5.85
147.70 ± 4.22
Haematocrit (L/L)
M
0.483 ± 0.02
0.500 ± 0.02
0.484 ± 0.02
0.489 ± 0.01
0.52 ± 0.02
0.51 ± 0.01
F
0.447 ± 0.03
0.452 ± 0.02
0.460 ± 0.02
0.465 ± 0.02
0.47 ± 0.02
0.48 ± 0.02
MCV (fL)
M
52.79 ± 1.57
53.48 ± 2.15
53.28 ± 1.61
53.83 ± 1.44
54.13 ± 1.81
53.10 ± 1.67
F
55.21 ± 1.76
54.52 ± 1.47
55.04 ± 1.40
54.62 ± 1.87
55.26 ± 1.32
55.20 ± 1.31
MCH (g/L)
M
16.52 ± 0.92
16.49 ± 0.83
16.40 ± 0.58
16.73 ± 0.58
16.73 ± 0.69
16.31 ± 0.74
F
17.16 ± 0.55
17.00 ± 0.56
17.09 ± 0.43
17.05 ± 0.67
17.12 ± 0.46
17.13 ± 0.47
MCHC (g/L)
M
313.00 ± 10.62
308.30 ± 5.33
307.60 ± 4.65
310.60 ± 6.64
308.80 ± 6.18
306.80 ± 5.20
F
310.80 ± 4.37
311.80 ± 5.65
310.80 ± 3.79
311.90 ± 5.43
309.90 ± 3.78
310.20 ± 6.55
Platelet count (109/L)
M
928.40 ± 94.46
943.90 ± 231.45
1012.30 ± 121.84
1034.90 ± 120.88
948.70 ± 195.72
1053.60 ± 140.93
F
968.90 ± 273.27
1018.80 ± 118.33
1095.50 ± 134.80
1095.70 ± 142.01
991.20 ± 163.15
1089.90 ± 114.91
Neutrophils (%)
M
16.75 ± 3.21
17.81 ± 4.38
20.49 ± 5.23
18.27 ± 4.27
17.40 ± 3.10
21.69 ± 4.19
F
17.30 ± 4.12
17.55 ± 3.80
20.37 ± 5.86
20.50 ± 8.59
18.76 ± 6.46
21.38 ± 5.79
Lymphocytes (%)
M
78.49 ± 4.49
78.35 ± 5.55
75.71 ± 5.49
78.00 ± 4.47
76.39 ± 3.63
70.92 ± 3.67
F
76.46 ± 5.12
76.78 ± 5.51
74.83 ± 6.24
73.79 ± 9.02
73.78 ± 7.51
68.30 ± 4.82
Monocytes (%)
M
1.87 ± 0.85
1.92 ± 0.84
1.90 ± 0.71
1.65 ± 0.51
3.08 ± 1.64
2.46 ± 0.89
F
2.03 ± 0.57
1.61 ± 0.37
1.87 ± 0.69
2.05 ± 0.71
3.34 ± 1.32
3.23 ± 0.79
Eosinophils (%)
M
1.85 ± 1.67
0.86 ± 0.47
0.92 ± 0.31
0.98 ± 0.77
1.74 ± 0.99
3.64 ± 2.70
F
2.55 ± 2.35
3.00 ± 3.35
1.98 ± 1.44
2.65 ± 2.35
2.38 ± 1.20
5.40 ± 3.43≠
Leukocyte count (%)
M
0.97 ± 0.16
1.02 ± 0.27
0.96 ± 0.23
1.11 ± 0.47
1.32 ± 0.43
1.23 ± 0.34
F
1.62 ± 2.05
1.01 ± 0.41
0.88 ± 0.35
0.95 ± 0.44
1.68 ± 0.71
1.67 ± 0.59
Basophils (%)
M
0.05 ± 0.05
0.07 ± 0.05
0.02 ± 0.04
0.03 ± 0.05
0.05 ± 0.05
0.06 ± 0.05
F
0.04 ± 0.05
0.05 ± 0.05
0.03 ± 0.05
0.03 ± 0.05
0.05 ± 0.05
0.04 ± 0.05
Reticulocyte count (%)
M
1.69 ± 0.47
1.86 ± 0.63
2.00 ± 0.49
1.74 ± 0.27
1.52 ± 0.35
1.29 ± 0.43
F
2.17 ± 1.58
1.71 ± 0.67
1.82 ± 0.69
1.45 ± 0.32
1.57 ± 0.51
1.56 ± 0.51
Clotting time (sec)
M
147.00 ± 29.83
153.00 ± 22.14
144.00 ± 23.66
147.00 ± 26.27
153.00 ± 22.14
150.00 ± 20.00
F
150.00 ± 20.00
147.00 ± 22.14
147.00 ± 22.14
144.00 ± 23.66
147.00 ± 22.14
147.00 ± 22.14
WBC: total leukocyte count; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RBC: erythrocyte count. Values are expressed as mean ± SD, n = 10; M: male; F: female. ,≠Significant from control recovery () in male and female.
