Assessment of Safety Profile of Activated Curcumin C3 Complex (AC³®), Enriched Extract of Bisdemethoxycurcumin from the Rhizomes of Curcuma longa

Table 7

Effect of 28 days exposure to AC³® on absolute organ weights (g) in Wistar rats.

Organs	Sex	Vehicle control	Treated			Control recovery	High dose-500 mg/kg b.w recovery
			Low dose-125 mg/kg b.w	Mid dose-250 mg/kg b.w	High dose-500 mg/kg b.w
Adrenals	M	0.061 ± 0.015	0.069 ± 0.014	0.069 ± 0.008	0.074 ± 0.010	0.055 ± 0.014	0.045 ± 0.007
	F	0.074 ± 0.018	0.069 ± 0.020	0.083 ± 0.022	0.056 ± 0.011	193.69 ± 9.60	200.47 ± 28.37
Liver	M	8.716 ± 1.269	8.904 ± 1.523	8.907 ± 1.657	8.875 ± 1.499	8.250 ± 0.954	8.318 ± 1.010
	F	6.114 ± 0.690	6.481 ± 0.749	6.773 ± 0.197	6.315 ± 0.638	0.504 ± 0.222	0.423 ± 0.044
Kidneys	M	1.773 ± 0.173	1.818 ± 0.422	1.705 ± 0.283	1.632 ± 0.341	1.646 ± 0.175	1.737 ± 0.067
	F	1.214 ± 0.133	1.287 ± 0.194	1.313 ± 0.169	1.242 ± 0.176	5.63 ± 0.77	6.11 ± 0.87
Heart	M	0.878 ± 0.018	0.878 ± 0.175	1.022 ± 0.197	0.896 ± 0.259	0.846 ± 0.060	0.977 ± 0.124
	F	0.610 ± 0.094	0.750 ± 0.126	0.734 ± 0.114	0.676 ± 0.145	1.175 ± 0.135	1.211 ± 0.151
Brain	M	1.859 ± 0.062	1.849 ± 0.144	1.720 ± 0.090	1.732 ± 0.163	1.726 ± 0.076	1.791 ± 0.118
	F	1.715 ± 0.053	1.688 ± 0.138	1.744 ± 0.083	1.705 ± 0.124	0.70 ± 0.11	0.67 ± 0.10
Spleen	M	0.711 ± 0.174	0.741 ± 0.104	0.894 ± 0.299	0.673 ± 0.146	0.748 ± 0.383	0.723 ± 0.185
	F	0.620 ± 0.127	0.582 ± 0.190	0.626 ± 0.154	0.490 ± 0.134	1.702 ± 0.068	1.732 ± 0.055
Thymus	M	0.366 ± 0.081	0.305 ± 0.120	0.347 ± 0.078	0.390 ± 0.113	0.370 ± 0.094	0.319 ± 0.047
	F	0.267 ± 0.051	0.364 ± 0.058	0.375 ± 0.100	0.309 ± 0.040	0.56 ± 0.12	0.50 ± 0.10
Ovaries	F	0.117 ± 0.007	0.122 ± 0.023	0.133 ± 0.012	0.140 ± 0.012	0.062 ± 0.024	0.060 ± 0.014
Uterus with cervix	F	0.558 ± 0.185	0.499 ± 0.023	0.133 ± 0.012	0.140 ± 0.012	0.10 ± 0.05	0.12 ± 0.04
Prostate	M	0.488 ± 0.133	0.500 ± 0.070	0.538 ± 0.192	0.465 ± 0.091	0.549 ± 0.132	0.490 ± 0.161
Seminal vesicle with coagulation gland	M	0.536 ± 0.170	0.584 ± 0.144	0.639 ± 0.255	0.489 ± 0.184	0.667 ± 0.194	0.650 ± 0.149
Testes	M	3.167 ± 0.201	3.046 ± 0.264	3.107 ± 0.227	2.775 ± 0.524	2.984 ± 0.203	3.034 ± 0.269
Epididymis	M	1.026 ± 0.051	1.135 ± 0.093	1.124 ± 0.144	0.900 ± 0.239	1.063 ± 0.117	0.987 ± 0.168

Values are expressed as mean ± SD, n = 5. M: male; F: female.