Assessment of Safety Profile of Activated Curcumin C3 Complex (AC3®), Enriched Extract of Bisdemethoxycurcumin from the Rhizomes of Curcuma longa
Table 5
Effect of 28 days exposure to AC3® on hematological parameters in Wistar rats.
Parameter
Sex
Vehicle control
Treated
Control recovery
High dose-500 mg/kg b.w recovery
Low dose-125 mg/kg b.w
Mid dose-250 mg/kg b.w
High dose-500 mg/kg b.w
WBC (109/L)
M
11.93 ± 1.92
12.94 ± 1.09
14.12 ± 1.77
16.90 ± 3.23
11.59 ± 5.17
13.17 ± 4.72
F
14.29 ± 2.65
11.51 ± 3.83
13.23 ± 4.27
13.93 ± 2.88
14.93 ± 2.76
12.49 ± 4.43
RBC (1012/L)
M
8.45 ± 0.75
8.25 ± 0.34
8.47 ± 0.43
8.50 ± 0.54
9.04 ± 0.26
8.85 ± 0.63
F
8.01 ± 0.54
8.31 ± 0.55
8.23 ± 0.37
8.12 ± 0.29
8.66 ± 0.47
8.57 ± 0.22
Hemoglobin (g/L)
M
148.00 ± 14.40
145.20 ± 4.55
145.80 ± 4.64
146.80 ± 2.95
158.00 ± 5.07
155.40 ± 8.20
F
144.40 ± 4.83
147.40 ± 6.58
147.40 ± 5.22
144.20 ± 3.70
151.80 ± 4.60
151.20 ± 4.71
Haematocrit (L/L)
M
0.47 ± 0.04
0.47 ± 0.01
0.46 ± 0.03
0.47 ± 0.02
0.494 ± 0.02
0.485 ± 0.04
F
0.44 ± 0.03
0.46 ± 0.03
0.46 ± 0.02
0.46 ± 0.01
0.464 ± 0.01
0.467 ± 0.02
MCV (fL)
M
55.84 ± 1.11
56.76 ± 2.06
54.74 ± 0.04
55.74 ± 1.93
54.62 ± 0.96
54.82 ± 1.00
F
55.40 ± 1.86
55.82 ± 1.57
55.80 ± 0.71
56.42 ± 1.16
53.68 ± 1.76
54.42 ± 1.51
MCH (g/L)
M
17.50 ± 0.43
17.62 ± 0.54
17.22 ± 0.45
17.30 ± 0.87
17.50 ± 0.47
17.58 ± 0.38
F
18.08 ± 1.06
17.76 ± 0.81
17.92 ± 0.42
17.80 ± 0.43
17.52 ± 0.64
17.68 ± 0.38
MCHC (g/L)
M
313.40 ± 4.88
310.60 ± 7.60
314.20 ± 6.14
310.80 ± 6.72
320.20 ± 7.26
320.80 ± 7.73
F
326.00 ± 12.75
318.20 ± 8.17
321.00 ± 7.78
315.60 ± 4.04
326.40 ± 3.97
324.40 ± 5.68
Platelet count (109/L)
M
862.80 ± 176.20
891.60 ± 149.13
997.40 ± 203.50
959.20 ± 156.55
1030.0 ± 190.90
1133.80 ± 92.82
F
966.60 ± 63.69
979.20 ± 118.27
1030.80 ± 41.59
984.40 ± 155.09
1084.0 ± 149.83
1041.60 ± 216.59
Neutrophils (%)
M
13.38 ± 5.83
18.74 ± 2.42
14.76 ± 5.63
25.40 ± 30.15
15.34 ± 7.09
17.16 ± 5.71
F
14.14 ± 4.08
16.24 ± 7.65
11.96 ± 3.05
13.38 ± 2.58
11.78 ± 2.29
20.08 ± 5.15≠
Lymphocytes (%)
M
82.50 ± 6.74
87.28 ± 2.62
81.14 ± 6.42
68.96 ± 28.98
79.74 ± 7.39
78.46 ± 5.96
F
81.72 ± 4.05
78.70 ± 9.39
82.60 ± 3.77
81.66 ± 2.51
83.64 ± 2.67
72.90 ± 4.93≠
Monocytes (%)
M
1.84 ± 0.67
1.22 ± 0.22
1.48 ± 0.69
1.62 ± 0.41
1.86 ± 0.59
1.80 ± 0.57
F
1.68 ± 0.34
1.64 ± 0.86
1.68 ± 0.68
1.96 ± 0.40
1.82 ± 0.36
2.18 ± 0.63
Eosinophils (%)
M
0.62 ± 0.36
0.48 ± 0.40
0.44 ± 0.23
0.20 ± 0.12
0.98 ± 0.47
0.74 ± 0.09
F
0.52 ± 0.28
1.16 ± 0.97
0.80 ± 0.40
0.70 ± 0.45
0.58 ± 0.40
1.70 ± 1.43
Leucocytes (%)
M
1.54 ± 0.34
2.22 ± 0.63
2.04 ± 0.23
3.68 ± 2.42
1.98 ± 0.49
1.76 ± 0.45
F
1.84 ± 0.54
2.16 ± 0.58
2.82 ± 1.07
2.26 ± 0.84
2.06 ± 0.72
3.06 ± 0.92
Basophils (%)
M
0.08 ± 0.04
0.04 ± 0.05
0.08 ± 0.04
0.08 ± 0.04
0.10 ± 0.00
0.08 ± 0.04
F
0.10 ± 0.00
0.08 ± 0.04
0.06 ± 0.05
0.12 ± 0.04
0.10 ± 0.00
0.08 ± 0.04
Reticulocyte count (%)
M
2.29 ± 0.49
2.52 ± 0.40
2.03 ± 0.81
1.83 ± 0.35
1.86 ± 0.47
2.06 ± 0.58
F
2.49 ± 0.82
2.10 ± 0.59
2.07 ± 0.18
2.14 ± 0.29
1.89 ± 0.52
1.95 ± 0.44
Prothrombin time (sec)
M
19.88 ± 1.57
18.70 ± 3.94
20.86 ± 1.11
20.10 ± 2.14
18.22 ± 1.58
18.02 ± 1.63
F
20.34 ± 0.83
20.28 ± 1.66
20.18 ± 1.21
19.40 ± 0.99
18.40 ± 1.36
16.98 ± 0.72
Clotting time (sec)
M
144.00 ± 25.10
144.00 ± 25.10
144.00 ± 25.10
150.00 ± 30.00
144.00 ± 25.10
144.00 ± 25.10
F
150.00 ± 30.00
144.00 ± 39.12
144.00 ± 25.10
144.00 ± 25.10
144.00 ± 25.10
138.00 ± 26.83
WBC: total leukocyte count; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RBC: erythrocyte count. Values are expressed as mean ± SD, n = 5. M: male; F: female. Significant from vehicle control () in male; ≠Significant from vehicle control recovery () in female.
